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pentobarbital will lower the level or effect of mestranol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Keep track of Intently (1)pentobarbital will minimize the level or effect of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Lack of, or reduced reaction to tofacitinib migh